Bacterial genetics
We study thermophilic bacteria and archaea, from their metabolism to CRISPR-Cas which defends them against viruses. In addition, we develop genome editing tools and optimise protein expression.
Since 1995, our researchers have focused on unravelling key aspects of the central metabolism of thermophilic bacteria and archaea, including their main enzymes, metabolic pathways and regulatory mechanisms. We have also conducted in-depth studies of the structural and functional relationships within selected enzymes.
CRISPR–Cas
In 2005, the lab launched a new study exploring prokaryotic host–virus interactions, aiming to uncover the molecular basis of CRISPR–Cas and Argonaute systems in bacteria and archaea. We are also developing general tools for genome editing and optimising protein expression by tuning transcription initiation and translation through systematic variation of the ribosome binding site, secondary structure and codon bias.
Metabolic pathways
Together with other research groups within the Microbiology chair group, we focus on synthetic biology of metabolic pathways and (eventually) entire cells. In addition, a research line focusses on the molecular characterization of selected intestinal microorganisms.
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Research themes
Bacterial genetics
We study thermophilic bacteria and archaea, from their metabolism to CRISPR-Cas which defends them against viruses. In addition, we develop genome editing tools and optimise protein expression.
Microbial evolution
Within this theme, we focus on exploring and characterizing the microbial diversity that exists on our planet and how this diversity came about.
Microbial physiology
To help create a sustainable circular economy, we investigate the physiology of the anaerobic microorganisms.
Molecular ecology
Research and education within the Microbial Ecology Group aims to understand and explore the functioning of microorganisms in natural and man-made ecosystems, including interdependencies with their living and non-living environments.